|
:: Endometriosis :: Endometriosis affects an estimated 176 million women worldwide regardless of their ethnic and social background. Many remain undiagnosed and are therefore not treated.1 What is Endometriosis?
Endometriosis is defined as the presence of endometrial-like tissue outside the uterus, which induces a chronic, inflammatory reaction. This estrogen-dependent disease is predominantly found in women of reproductive age, and generally becomes inactive with menopause, unless a woman uses post-menopausal hormone therapy. The associated symptoms can impact on general physical, mental and social well-being.2,3 What are the symptoms of Endometriosis?
The most common symptom of endometriosis is pain in the lower abdomen or pelvis, or the lower back, mainly during menstrual periods. The amount of pain a woman feels does not depend on how much endometriosis she has. Some women have no pain, even though their disease affects large areas. Other women with endometriosis have severe pain even though they have only a few small growths.4
Symptoms of endometriosis can include:
How to detect Endometriosis?
To detect endometriosis, the health care provider will perform a physical exam, including a pelvic exam. Tests that are done to help diagnose endometriosis include:
What are the risks and complications of Endometriosis?
Endometriosis can lead to infertility, especially those with mild endometriosis. How to prevent Endometriosis?
There are no definite ways to lower the chances of getting endometriosis. Otherwise, lower the level of estrogen in the body might help to prevent endometriosis, since estrogen is involved in thickening the lining of the uterus during the menstrual cycle.4 How to treat Endometriosis?
Treatments for endometriosis pain may include pain medications, hormone therapy, and surgical treatment.
Doctors will recommend hormone medicines to treat endometriosis, when pain medications are not enough to counter the pain. Only women who do not wish to become pregnant can use these drugs. Hormone treatment is best for women with small growths who do not have bad pain. Common hormones used for endometriosis include 4,5: Surgery may be recommended if you have severe pain that does not get better with other treatments. Surgery may include 4,5:
Dismeno Dismeno containing DLBS1442 which has been developed from Phaleria macrocarpa, works by regulating estrogen and progesterone receptors, downregulating anti-inflammatory genes and inhibiting proliferation of endometriotic tissue, that effectively helpsto treat endometriosis.7 In addition, Dismeno also reduces the pain caused by endometriosis (dysmenorrhea). Source
DLBS1442 is a Bioactive Fraction extracted from Indonesian native herbal, Phaleria macrocarpa. The molecular mechanism of DLBS1442 on hormone receptors was investigated. Effect of DLBS1442 was studied using RL 95-2, endometrial carcinoma cell lines from which the total RNA was isolated to observe the response of estrogen and progesterone receptor genes. DLBS1442 was found to possess the capability in downregulating estrogen receptor gene expressions and on the other hand, upregulating progesterone receptor gene expressions in a dose-dependent manner. Furthermore, DLBS1442 is preclinically proved to have anti-inflammatory, apoptosis induce, and antiangiogenic effects. DLBS1442 exerts its anti-inflammatory effect through selective inhibition of COX-2, an inducible prostaglandin synthase and also cPLA2. Thus, by inhibiting cPLA2 and COX-2 in synthesizing prostaglandin, as well as inhibiting proliferation of endometriotic tissue, DLBS1442 can reduce menstrual pain. DLBS1442 is also studied clinically for its efficacy and safety in alleviating symptoms of primary dysmenorrhea. DLBS1442 was safe and well tolerated in women with premenstrual syndrome and/or dysmenorrhea.
Composition: Each capsule contains: Bioactive Fraction DLBS1442 Phaleria macrocarpa 100 mg. Usage: Helps to relieve menstrual pain. Warning and precautions Only use on doctor’s recommendation. During treatment, consult your doctor regularly. Adverse reaction No side effects have been reported. Considered safe if taken in the recommended dosage. Presentation and registration Box, 5 strips @ 6 capsules, POM HT. 152.300.481
What is Dismeno? Dismeno is a prescribed therapy for dysmenorrhea patients including those who suffer from endometriosis. Dismeno prevents endometriosis development by conferring its pharmacological actions including downregulating estrogen receptor and upregulating progesteron receptor, downregulating cPLA2, COX2, and PGE2 expression, as well as inhibiting proliferation on endometriotic tissue. Contraindications to take Dismeno You should not take Dismeno if you have hypersensitivity to one or more of its components. How should I take Dismeno? Dismeno should be taken three times daily, but can be customized following your doctor’s instructions. You may take Dismeno with or without food. Take the capsule with a glass of water. What happens if I miss a dose? If you miss taking a dose of Dismeno, take it as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What should I do while taking Dismeno? Try to have a regular exercise, keep a low amount of body fat, and avoid consumption of alcohol and drinks with caffeine. Dismeno side effect No side effects have been recorded during the toxicological and clinical studies. Dismeno is considered safe if taken at the recommended dosage. If you experience any side effect that might be caused by Dismeno, call your doctor as soon as possible. Interaction of Dismeno with other drugs Dismeno does not interact with other medication. What should I tell my doctor/pharmacist?
What storage conditions are needed for Dismeno?
Dismeno must be stored at a temperature below 30°C.
:: Dismeno in the world :: |