PT Dexa Medica as one of the most reputable pharmaceutical companies in Indonesia has been doing research since 2005 to find active medicinal raw material with which to produce modern herbalmedicine. Through DLBS (Dexa Laboratories of Biomolecular Sciences), PT Dexa Medica has been doing research and found various active herbal medicinal ingredients from Indonesian natural resources.

"DLBS PT Dexa Medica has found various active ingredients for herbal medicine. This would have national competitiveness advantages. Therefore, research and development of herbal medicine need to be boosted," said Executive Director DLBS PT Dexa Medica, Dr. Raymond R. Tjandrawinata, MBA, PhD, FRSC, to the national and regional media at DLBS Building PT Dexa Medica, Cikarang, West Java, on Wednesday, January 27, 2016.

Medicinal ingredients produced by the production facility in DLBS PT Dexa Medica, said Raymond Tjandrawinata, are the results of our own research coming from Indonesian biodiversity, starting with biomolecular research, animal pharmacology test, until clinical trials to patients in various cities in Indonesia.

The excellences of Herbal Medicine active ingredients from Indonesian natural resources produced by DLBS PT Dexa Medica are;

  • Using Indonesian biodiversity.
  • Using modern pharmacology principles & biomolecular approach in finding new medicine.
  • Clinical and preclinical testing to complete medical evidence, according to the Good Clinical Practices (GCP) principles.
  • Ethical animal testing in accordance with AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International) certification.
  • Produce with standardized facilities: Good Active Raw Material Production Method, Good Traditional Medicine Production Method - natural ingredients extracts industry, and international requirements, such as ISO22000 and HACCP.
  • Loaded with Intellectual Property Right (HaKI) content.

DLBS production facilities PT Dexa Medica have met the requirements of Natural Ingredients Extract Industry (IEBA) as contained in the Regulation of the Minister of Health of the Republic of Indonesia Number 006 year 2012 about Traditional Medicine Business and Industry.

Production facilities owned by DLBS have been through a validated process in a production system with modern technology support, and have been certified by Halal Assurance System with A grade, AAALAC international and certified by ISO 22000:2005 (Food Security Management System).

While DLBS finished goods production facilities are produced at PT Dexa Medica production facilities that have been certified by GMP (Good Manufacturing Practices) certificate, Good Traditional Medicine Production Method, ISO 9001:2008, and ISO 14001:2004. 

DLBS Found Various Indonesian Herbal Medicine Active Raw Materials

Raymond R. Tjandrawinata added that DLBS has a vision to become a research based organization for the invention, development, and production of pharmaceutical, biopharmaceutical, and nutraceutical products. Since 2011, result products of DLBS, Bioactive Fraction, have been marketed by PT Dexa Medica and have met the requirements of the Ministry of Health regulation number 006, year 2012.

"Medicinal raw material produced by DLBS production facilities is the result of our own research from Indonesian biodiversity. It starts with biomolecular research, animal pharmacology tests, until clinical trials to patients in various cities in Indonesia," said Raymond R. Tjandrawinata.

DLBS PT Dexa Medica has had the commitment to new drug research since 2005. The research done by DLBS PT Dexa Medica is different from research done by other pharmaceutical companies. Natural raw material research by DLBS PT Dexa Medica is conducted in the form of herbal, biotechnological and microbial research.

DLBS PT Dexa Medica’s success in producing active raw material of herbal medicine also supports the government program in the field of National Medicinal Active Raw Material Autonomy. Also, this momentum gave extra credit to Indonesia because herbal medicine active raw material produced by DLBS has been patented not only in Indonesia but also internationally through the Patent Cooperation Treaty.

Researchers in DLBS study the candidate of herbal medicine active raw material for the chemical and biological aspects at the molecular level through a process called TCEBS (Tandem Chemistry Expression Bioassay System). TCEBS is a method of systematical filter to find the most active and potential candidate for the studied product following a bioassay system which harness gene expression and protein array technique.

DLBS PT Dexa Medica production facilities in Cikarang, West Java are able to produce herbal medicine active raw material in the form of Bioactive Fraction. "We are the first pharmaceutical company in Indonesia to produce Bioactive Fraction from herbal ingredients," he said.

It was Ministry of Health of the Republic of Indonesia, dr. Nafsiah Mboi, SpA, M.P.H., who gave the Natural Resource Extract Industry license and inaugurate the Bioactive Fraction DLBS Dexa Medica Production Facility on Tuesday, August 20, 2013.

The growing of herbal medicine active raw ingredients production will encourage herbal medicine plant farmers to increase the supply of medicinal plant ingredients. Nationally, it would impact the strength of the national economy, said Raymond Tjandrawinata.

The following are the modern herbal medicine products researched by DLBS from Indonesian natural ingredients and produced by PT Dexa Medica:

  • HerbaVOMITZ is a modern herbal medicine made from natural herbal Zingiber Officinale (ginger) processed with modern technology ‘Advanced Fractionation Technology (AFT)’, to produce active substance Avominol. AFT is an extraction process to gain a specified fraction which has biological activity to alleviate bloating and nausea. Consumption dosage is 1-3 times daily until the symptoms are gone, and depends on each person's body condition. Every HerbaVOMITZ tablet contains Avominol 150 mg.
  • HerbaKOF is a modern herbal medicine made from natural herbs from Legundi leaves, Ginger, Saga leaves and Mahkota Dewa fruit extract processed through modern technology, 'Advanced Fractionation Technology (AFT)' to produce active substance Reconyl™. HerbaKOF is safe to be consumed by anyone, including breastfeeding mothers and children above 6 years old. HerbaKOF dosage for adults is: 15 ml three times daily and for children above 6 years old, 5 ml three times daily.
  • Inlacin is an oral anti diabetic medicine for patients with type 2 diabetes (not relying on Insulin). Inlacin works by lowering insulin resistance and increasing glucose intake by cells. Inlacin, which contains Bioactive Fraction DLBS3233 developed from Lagerstroemia speciosa and Cinnamomum burmannii,  works by increasing the sensitivity of glucose and insulin intake. During the clinical trials, Inlacin shows ability in controlling blood sugar, insulin levels, and lipoprotein including High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), triglycerides, and total cholesterol level.
  • Disolf contains extract DLBS 1033 Lumbricus rubellus 490 mg, that efficacious helps blood circulation. Disolf dosage for adults: Treatment (1-2 tablet, 3 times daily, 0.5 - 1 hour before meals), Prevention (1 tablet, 2 times daily, 0.5 - 1 hour before meals).
  • Redacid helps alleviate disorders of the stomach by reducing gastric acid and serves as gastroprotector. Redacid contains Bioactive Fraction DLBS2411 fractionated from the Cinnamomum Burmannii herb.
  • Vitafem Free Me is a modern herbal medicine, which contains Bioactive Fraction DLBS1442 from Phaleria Macrocarpa fraction - indicated for Premenstrual Syndrome (PMS). Premenstrual syndrome is characterized by the emersion of emotional and physical symptoms during the phase before menstruation. Bioactive Fraction DLBS1442 could reduce pain appearing before and during menstruation.
  • Phalecarps is a modern herbal medicine containing Bioactive Fraction DLBS1425 and has been developed from Phaleria Macrocarpa to treat breast cancer and other solid cancers. With its ability as antiproliferative, anti-inflammatory, and antiangiogenic, Phalecarps pharmacologically is good for the treatment of breast cancer and other solid cancers.
  • STIMUNO is a fitofarmaka herbal medicine for immunomodulator (immune system booster) made from Indonesian herbal medicine (Phyllanthus niruri- Meniran), that could increase the immune system. STIMUNO is available in the form of syrup for kids and STIMUNO Forte in the form of capsule for adults. Recently STIMUNO launched new variant, namely grape