Mechanism of action

Prescribing information

Patient information

Resindex in the world

:: Diabetes ::
Statistics and Facts
Diabetes is a non-communicable disease affecting the population worldwide. About 366 million people, have been living with diabetes in 2011, with 183 million people (50%) are undiagnosed. By 2030, it is estimated to grow to 552 million, according to the Diabetes Atlas 5th edition.

What is Diabetes?
Diabetes (or Diabetes Mellitus) is a chronic disease that occurs when the body cannot produce enough insulin or use it effectively. Insulin is a hormone produced by the pancreas that helps cells to absorb the blood glucose. A problem in the production or use of insulin leads to an accumulation of sugar in the blood (hyperglycemia). This is associated with long-term damage of various organs and tissues. 1,2

Type 1 diabetes
Type 1 diabetes (previously known as insulin-dependent, juvenile or childhood-onset) is characterized by deficient insulin production due to auto-immune reaction against the pancreas cells and requires daily administration of insulin. The cause of type 1 diabetes is not known and it is not preventable with current knowledge.

Gestational diabetes
Gestational diabetes is hyperglycemia with onset or first recognition during pregnancy. It usually disappears after pregnancy but women with gestational diabetes and their offspring are at an increased risk of developing type 2 diabetes, later in life.

Type 2 diabetes
Type 2 diabetes (formerly called non-insulin-dependent or adult-onset) is characterized by insulin resistance and relative insulin deficiency. It accounts for at least 90% of all cases of diabetes. There are increasing reports of children developing type 2 diabetes.

Type 2 diabetes is often, but not always, associated with obesity, which in itself can cause insulin resistance and lead to elevated blood glucose levels. It is strongly familial, but major susceptibility genes have not yet been identified. There are several possible factors in the development of type 2 diabetes. These include:

  • Obesity, diet and physical inactivity
  • Increasing age
  • Insulin resistance
  • Family history of diabetes
  • Less than optimum intrauterine environment
  • Ethnicity

The rising prevalence of type 2 diabetes is associated with rapid cultural and social changes, aging populations, increasing urbanization, dietary changes, reduced physical activity and other unhealthy lifestyle and behavioral patterns 3

What are the symptoms of type 2 Diabetes?
Here are the most commonly experienced signs of diabetes:

  • Frequent urination
  • Excessive thirst
  • Increased hunger
  • Weight loss
  • Tiredness
  • Lack of interest and concentration
  • Vomiting and stomach pain (often mistaken as the flu)
  • A tingling sensation or numbness in the hands or feet
  • Blurred vision
  • Frequent infections
  • Slow-healing wounds

These symptoms are often subtle. As a result, the disease may be diagnosed several years after onset, once complications have already arisen. 2,4

How to detect and control type 2 Diabetes?
According to the Diabetes Atlas 5th edition, 80 % of people with diabetes are diagnosed in low and middle-income developing countries.
The diagnosis of type 2 diabetes usually occurs between the ages of 40 to 59 years but could occur earlier, especially in populations with high diabetes prevalence.

Early diagnostic can simply be made by inexpensive blood testing. However, type 2 diabetes can remain undetected for many years and the diagnosis is often made from associated complications or incidentally through an abnormal blood or urine glucose test. 5

What are the risks and complications of type 2 Diabetes?
Diabetes is a disease causing blindness, renal and kidney failure, nerves damages (tingling, pain, numbness, or weakness in the feet and hands) and lower limb amputation. It is also now one of the leading causes of death, largely because of a markedly increased risk of coronary heart disease and stroke (cardiovascular disease).

The mechanism by which diabetes leads to these complications is complex, and not yet fully understood, but involves the direct toxic effects of high glucose levels, along with the impact of elevated blood pressure, abnormal lipid levels and both functional and structural abnormalities of small blood vessels. 1,2

How to prevent type 2 Diabetes?
Simple lifestyle measures have been shown to be effective in preventing or delaying the onset of type 2 diabetes. To help prevent type 2 diabetes and its complications, people should:

  • Achieve and maintain healthy body weight;
  • Be physically active – at least 30 minutes of regular, moderate-intensity activity on most days. More activity is required for weight control;
  • Eat a healthy diet of between three and five servings of fruit and vegetables a day and reduce sugar and saturated fats intake;
  • Avoid tobacco use – smoking increases the risk of cardiovascular diseases. 2

How to treat type 2 Diabetes?
People with type 2 Diabetes will be treated with oral medication which, in specific cases, can be associated with insulin. Several treatments exist, targeting different body mechanisms, specific to each patient’s tolerance and reaction.

Resindex, which containing DLBS3233, has been developed from Lagerstroemia speciosa and Cinnamomum burmannii, works by increasing glucose uptake and insulin sensibility. During clinical studies, it showed a property to control blood sugar, insulin level and other lipoproteins including High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), triglycerides, and total cholesterol level.

Resindex is an effective option to treat people with type 2 Diabetes and possibly also for diabetes prevention.

1. International Diabetes Federation. About Diabetes.
2. World Health Organization. What is diabetes?
3. International Diabetes Federation. Types of Diabetes.
4. International Diabetes Federation. Warning signs of Diabetes.
5. World Diabetes Fundation. Diabetes Facts.

:: Mechanism of action ::
Resindex 50 & 100 mg DLBS3233 is a bioactive fraction containing Lagerstroemia speciosa and Cinnamomum burmannii. These herbals were developed through particular processes, resulting in a bioactive fraction with special characteristics and certain biological activities.

The combination of these two herbals works in a synergistic way such that its effect on diabetes is better than that achieved by the single use of any of the components. Preclinical studies of DLBS3233 showed its effect in reducing blood glucose levels.

The results specifically depicted that this bioactive fraction increased the expression of PI3 Kinase, Akt, GLUT-4, PPAR γ and PPAR δ on the mRNA level of 3T3 Swiss Albino Pre-adipocyte cells. It also reduced the expression of resistin gene and increased that of Glut-4 and adiponectin on the mRNA level. This result is supported by a randomized, double-blind, and controlled DLBS3233 clinical study.

DLBS3233 administered to OHA-naïve type 2 Diabetes, showed a property to control blood sugar, insulin levels and other lipoproteins including High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), triglycerides, and total cholesterol level. Therefore, DLBS3233 conveys medical utilities for type II diabetes treatment, and, possibly also for diabetes prevention.  

:: Prescribing information ::


Each capsule contains:

Bioactive Fraction DLBS3233 Lagerstroemia speciosa & Cinnamomum burmannii 50 or 100 mg.


As a combination therapy to oral medication for Type-2 Diabetes Mellitus patients.


Dosage & administration:

1 capsule daily


Warning and precautions
For diabetic patients determined by prescription only. - During treatment, consult your doctor periodically.

Adverse reaction
No side effects have been reported. Considered safe if taken in the recommended dosage

Presentation and registration

  • Box, 5 strips @ 6 capsules RESINDEX 50, POM FF. 152.300.611
  • Box, 5 strips @ 6 capsules RESINDEX 100, POM FF. 152.300.621 

:: Patient information ::
What is Resindex?
Resindex is an oral anti diabetic prescribed for patients suffering from type 2 diabetes (non insulin dependent). It works by decreasing your insulin resistance and increasing your glucose uptake by the cells.
Resindex can be taken alone or in association with other oral treatments and / or insulin if needed. Under no circumstance can it treat type 1 Diabetes.
Resindex can also be used to prevent and delay the onset of type 2 diabetes.

Contraindications to take Resindex
You should not take Resindex if you are allergic to one or more of its components.

How should I take Resindex?
Resindex should be taken once daily, but can be customized following your doctor’s instructions. You may take Resindex with or without food. Take the capsule with a glass of water.

What happens if I missed a dose?
If you miss taking a dose of Resindex, take it as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What should I do while taking Resindex?
In order to treat and control your type 2 diabetes, you should:

  • Achieve and maintain a healthy body weight;
  • Be physically active – at least 30 minutes of regular, moderate-intensity activity on most days. More activity is required for weight control;
  • Eat a healthy diet of between three and five servings of fruit and vegetables a day and reduce sugar and saturated fats intake
  • Avoid drinking alcohol while taking Resindex. It lowers blood sugar and may interfere with your diabetes treatment
  • Avoid tobacco use. Smoking increases the risk of cardiovascular diseases.

This will help your body manage the disease, control it to delay the risks (blindness, renal and kidney failure, nerves damages, heart disease, stroke, etc) that frequently occur in diabetic patients and help Resindex being more effective.
Frequently consult your doctor while taking Resindex.

Be careful not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Resindex side effects
No side effects have been recorded during the toxicological and clinical studies. Resindex is considered safe if taken at the recommended dosage.
If you experience any side effect that might be caused by Resindex, call your doctor as soon as possible.

Interaction of Resindex with other drugs
Resindex does not interact with other medication.

What should I tell my doctor / pharmacist?

  • Always tell your doctor / pharmacist if you are taking any other medicine or food supplements.
  • Always tell your doctor / pharmacist if you have any allergy.
  • Women should tell their doctor / pharmacist if they are pregnant or planning to get pregnant

What storage conditions are needed for Resindex?
Resindex must be stored at a temperature below 30°C.
It must be kept from light and out of reach of children.

:: Resindex in the world ::
Resindex is marketed in Indonesia and currently under review in other countries. Our goal is to offer the possibility for patients globally to have access to Resindex. If you are interested in partnering with us, please see the partnership page in this website or contact us directly.